A problem I found with the 559-size 60mm Big Apples was that there was no fenders that would fit around them.

There are lots of fenders that are wide enough, but the problem is that the outer diameter of the center of the tire is too big to fit inside the radial curve of most fenders. The tire rubs at the forward and back ends of the fenders.

If you had metal fenders maybe you could bend them out a bit more, but 99% of bicycle fenders now are plastic that you can't easily reshape....

So if you want to be able to run fenders at all, you should probably stick to the 50mm tires.