yes, you will notice the difference.
and no, it's still not low enough for heavy loaded touring
in big hills. 16-18" mucho gooder.

so you can barely ride it in that 22" gear on flat ground?
course not! those gears are not meant for flat ground.
is the same as saying 108" gears are useless cause
you can barely ride up a 22% incline.

the point of super low gears is you can ride up really
steep hills for a really long time WITHOUT getting
exhausted. don't know about others, but i can ride
up a 10-12% for 6 hours straight at 6 km/h without
getting winded. (32-40 km long hills) okay, maybe
a couple pee breaks, and some stops to take photos....

you're not "spinning" up at 120 rpm wearing yourself
out. that's fine on a short stretch, but for long hills
pretty much continue at the same cadence as the flats,
just moving forward slower.....much slower.