I'll respectfully disagree with this point, for aggressive road bike riding anyway. Changing from a 2,000g wheelset to a readily available and affordable 1,500g wheelset shaves a pound off your rotating mass and is definitely noticeable when accelerating. There can be side effects though, like ride harshness and "feel" so it's not always about less rotating mass.

To the OP, you mention hybrid wheels... as in for a hybrid bike? If you have a hybrid-ish bike for which you are pondering this upgrade, I'll side with those who are telling you to stick with the wheels you already have.