My Selle Anatomica Titanico is my 8th saddle in 2 years. I have never willingly changed a saddle. The process works like this:

Step 1: test ride saddles, as many as needed. 8, 10, more.
Step 2: find the one that fits the best
Step 3: buy it, ride it for 2-3 months
Step 4: saddle suddenly turns evil and tries to murder my nethers
Step 5: return to Step 1

As of today the Titanico is approaching a previously unseen number of miles without becoming evil. I remain cautiously optimistic.