Lots of good answers above. I also have little trouble with most saddles - just a few I knew right away weren't going to get comfy. My best fit is with Selle Italia Flites with light padding. Generally over $100, but they've never disappointed me. My worst fit was an oem WTB that looked like it was engineered to be comfy, but it was a real pain machine.
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My C&V Bikes:
1972 Bottecchia Professional, 1972 Legnano Olympiade Record,
1982 Colnago Super, 1987 Bottecchia Team C-Record,
1988 Pinarello Montello, 1990 Masi Nuova Strada Super Record,
1995 Bianchi Campione d'Italia, 1995 DeBernardi Thron