I wanted to use the inner for timing but twocircle advised against it based on chainline from the outer position and 2x rear dérailleur positioning. I'm glad I took his advice, the inner and middle are perfect with the inner positioned 52 sitting in line with the 5th cog. The cassette did move 1.85mm to the spoke side going to 11 speed on my hub. The Eagle will move further inboard as the shape of the cassette puts the 42 and 50 inside of the freehub body. And you won't have a RD.

My real problem with using the triple was the 52 on the inner gets very close to the chainstay and rubbing. My clearance is currently 3.5mm, I'm thinking or removing 2mm of that to improve the Q factor a little more.

However, I believe the only limiting factor on your choice of crank is the potential rubbing by the chainring on the chainstay. A 50 ring would have solved my problem with a standard crank axle. I suggest measuring up with a standard double crank to see your clearances with the chainrings you want to use. If there is adequate clearance with a standard double and you can mount the left side crank properly you are in the clear.

And then you just have to get used to the big jumps between gears.