Originally Posted by IK_biker

You may like it, or you may not.
I have done this (Apidura seatbag & half-frame bag plus the front Ortliebs), and discovered that the lack of easy access to items I carry was very detrimental. Even adding or removing a clothing layer was cumbersome.
This is why I evolved to deploy the kit I described in post #23 in this thread.

The framebag/seatbag combo works nicely on my distance bike for short stints (overnighters or exended weekend trips with 2 overnights), assisted by a largish Acorn bag onto a front mini-rack. These short trips are mostly focused on the riding aspect when I don't pay much attention to conveniences, comforts and some such. During those I carry no spare clothing, and only a minimalist kitchen and bedding. Hence, I don't miss the inability for easy access to my "stuff".