Sealskinz aren't waterproof for more than an hour or two of hard work when it's real wet out. Neoprene isn't waterproof really at all, just doesn't water log and insulates well, but not alone. Decent wool beneath neoprene socks with a good seal at the ankle is excellent, but to really work you have to be able to fit it all in your shoe and still have plenty of room to move all of your toes. Then it works all day long, your feet are moist but it isn't noticeable because they'll not get sopping wet with wool against the skin and neoprene above the wool.

I normally wear a 43 or so but in th ewinter it's 45