If you can really tell one frame from another from another in terms of comfort, efficiency, speed, etc; that is, if you really have something like an objective reason to prefer one to another; AND if you find one component group superior in some similarly quasi-objective standard, then it makes sense. If not, well, then, not. Which is not to say "don't do it!", but rather, do it if you want to.

As for me, I cannot say any of my frames feel different from any of the others. The differences I feel are the different components, and I like the feel of different components and in particular different contact points for my hands. In many cases they are different but equal. Maybe that's just me. Do what you like, or do what you want, your call.