one of the things I have noticed is that many of the rims are just not stiff enough and will egg as we ride (have a flat spot at the bottom of the wheel) which ends up taking the wheel out of true and messing up the spoke tension.
I picked up my Rolf Prima wheels and they are a 33mm deep V wheel, and Rolf indexes their spokes way different than other wheel manufacturers. I am at 345 pounds now, but picked up the Rolf wheels when I was at 360 pounds. The Rolf wheels I have are 24 spokes front and 24 spokes rear.
the extra stiffness of the wheel means they stay round when I ride, and riding is less effort (more speed for the same power output and cadence).
I hope your new wheels work for you.