The extra weight is obvious but actually the main drawback of these tubes is the added rolling resistance. When the tire is rolling the rubber in these tubes has to be flexed in the area of the contact patch and that requires energy. I could see using them for a short commute in an area with lots of potential for flats (goat heads, other thorns, glass, etc.) where the added time from riding slower would be minimal and much more acceptable than sometimes having a longer delay to fix a flat.