Saddle sore = some chamois cream, vaseline works.

Saddle discomfort = find the right one.

I've test ridden 20 plus saddles and purchased a few, ranging from WTB padded saddles to Sella SMP, which I rode for year on rides up to 190 miles, thought it was okay. But - finally - after everyone kept talking about Brooks Brooks Brooks ... I tried one. They are clunky and bulky and don't match a $5000 carbon road bike and we all want to look cool, but it was obvious after a few rides that what they say is true. Brooks wins. I'm riding faster simply because my mind is no longer on my butt, i.e. I can exert power more evenly through the pedal stroke without being distracted by discomfort. Try a Brooks if you are not entirely happy with the Fizik.