I would go disc...I value the wider range of tire sizes that it accommodates purely from a comfort perspective. I recently made this switch and ride 28c Schwalbe Pro Ones as daily drivers (31.7mm at widest section). Thru axle and flat-mount disc make removal and re-installation of the wheels a breeze - something I value given that I often travel with both wheels off.

On aesthetics, it depends on the specific frame...I really like the sparseness of the seat-stays on my Domane wherein there is no cross-brace where a traditional caliper would sit...I think it looks fantastic how the wheel/tire just lives inside the large gap:



For some more traditional (non-endurance frames), I can appreciate the aesthetics of the compactness of a direct-mount caliper brake.