Not at all. The bag itself is taller than it is wide, it's barely 2" wide when fully stuffed. I run a straight Thomson, and with the shape of my saddle, it (was) impossible to come into leg-contact with the bag.

I've since added the Wolftooth B-Rad to my bag mounting setup, so there's zero chance of it contacting anything. I don't like saddlebags on principle, but use them as compromise. The stuff from Wolftooth makes it a not-saddlebag, and that I like.