Hand position IME has been more a function of the bars. When I set up a bike I have a single number of top tube + stem length which is my personal definition of "reach". My personal number is 69 cm that I have used for numerous bikes and it has worked well for me. The handling and feel of the bike can vary greatly according to the bars and position of levers on them, so for me that is where a lot of the tweaking of fit goes in. I have a couple of types of bars that I know I like and tend to put those on my bikes when I can.
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N = '96 Colnago C40, '04 Wilier Alpe D'Huez, '10 Colnago EPS, '85 Merckx Pro, '89 Merckx Century, '86 Tommasini Professional, '04 Teschner Aero FX Pro, '05 Alan Carbon Cross, '86 De Rosa Professional, '95 Gios Compact Pro, '95 Carrera Zeus, ‘81 Masi Gran Criterium, ‘81 Merckx Pro, ‘89 Cinelli Supercorsa, ‘83 Bianchi Specialissima, ‘VO Randonneur, Ritchey Breakaway Steel, Rivendell Rambouillet, Heron Randonneur, ‘92 Ciöcc Columbus EL