For hand pressure, here are some things to try.
1. Move saddle back
2. Longer stem
3. Make sure you are resting your hands on the base of your palm and not in the middle
4. Move your position of your hands throughout the ride
5. Tilt the saddle slightly up
6. Make sure your reach is correct
7. Gel under your bar wrap helps
8. Giro Super Gel gloves