Well I tried raising the nose of the saddle and found that indeed, it did help lessen the pressure on the web between thumb and forefinger. OTOH, the riding position was not as comfortable, so about 10 miles into my ride yesterday, I lowered the nose of the saddle.

Not sure if that comfort issue is simply a matter of getting acclimatized to the new position or just what. But it felt better after I lowered the nose.

One thing I do NOT like about my Madone 5.5 is the saddle adjustment. It's one of those infinitely adjustable things that tighten into a new position from the position you set it too, so it tends to take a lot of fiddling to change and it's hard to make minute, incremental changes. My previous Pilot 5.2 was infinitely better at changing/adjusting saddle position than this thing is.