i have had as many as 10 patches on a tube at one time with no probs...
sometimes having as many as 4 punctures in one day. i seem to have trouble with those "glueless" patches they seem to separate around the edges in a couple of months.
it seems for me i get the best use out of regular glue patches & carry 2 tubes.
i had 5 of those peel'n'stick patches on a tube before & after a while they seemed to compound air seeping problems.
occasionally i use those when i get home i remove it & put a gluepatch on.