Originally Posted by
Racing Dan
No, the power at the crank is the same, but one rider may tire faster than the other, even if they are identical, due to the physiologic effects of riding a different cadences. The debate then, is what cadence is the best. The answer to that question is, Imo, it depends ... :-)
But what about at the wheel
A lower cadence and/or a better chainline will have lower drivetrain friction losses