Well, if it was patch a patch or sacrifice a ride, I probably would patch a patch.
But so far once a tube fulfils that criteria its so generally worn and well used that retiring it doesn’t bother me. The cost-per-mile or week is well down into the range of pointlessness.
And it’s not concerns about adhesion that discourages me to patch a patch, its flexibility.
Patches do influence how a tube stretches, and uneven stretching is a fairly accepted suspect in ”mystery” flats. Once you get patches forming 1/3 or more of a ring around the tube the remaining single-layer area will have to stretch a fair bit more.
Might not be a problem if you run your tubes wide.
I use one seat bag that I transfer between bikes, so sometimes My spare tubes has some stretching to do. I feel more confident in My equipment when there’s only one obvious waist on the tube.