Based on my own experience, a good and comfortable bike fit is a variable thing that is dependent on fitness level and length of ride. The bike that is perfectly comfortable for a 5 to 10 mile ride may cause considerable discomfort during a 50 to 70 mile ride. I've found that as my rides got longer I kept fiddling with bike fit which improved comfort over several years. During those same years, my body got stronger but I also did some exercises to strengthen those muscles that were not up to the task. For example, neck muscles got sore early on in a low position. That situation improved with neck exercises.
So I would say, keep tweaking your bike fit as seems necessary and be aware it will change over time. The one tip I have found helpful in making changes is to mark, say with a white out marking pen, the position of the handle bar and seat post. Then if a change does not seem to work out, it is simple to get back to the previous position.