This is precisely the pedelec I actually own, hehe.

So I can comment on Rohloff at 45kph. First, when Bosch sends an ebike manufacturer documents on operation of motors on gearhubs, they cleverly completely ignore the very idea of having Rohloff on the HS motor. I think they want to avoid guaranteeing anything, even in spite of the fact that both R&M and others (e.g., Heisenberg) use Rohloff+speed motors. So manufacturers do go for Rohloff+speed, but I don't know what Bosch thinks about this.

So, what can I say? Well, there are corner cases when the chain comes off. This typically happens on challenging terrain when you put the bike in low gear and the motor applies insane amount of torque against lack of torque, but then suddenly the bike catches the ground good, all this torque forces the gear hub to go neutral, chain comes off the Rohloff hub and also starts going around the front sprocket.

Not nice. But chain going around the front sprocket is also a problem with derailleurs. In fact, it's much worse because the chain is very long, bouncing around, and whenever its natural flexibility is damaged (by mud, of course), it wraps around the sprocket and forces me to choose a large rear sprocket (i.e., go into a low gear).