With all the talk of saddle, Did anyone mention shorts? Try some different shorts to find a pad your bottom appreciates.

For me it's all about changing positions and off the saddle - on long rides (as mentioned by [MENTION=413312]WNCGoater[/MENTION] and others) . i try to raise my butt about 1.0mm (or so) off the saddle for periods of time when riding at about the 18 - 20 mph range. This shifts the burden of weight bearing to the legs but ever-so-slightly, practiced regularly it almost becomes second nature. I also like saddles with long noses for facilitating different positions. And sometimes you just need to get out of the saddle for better air flow in that region to maximize cooling. A short break off the bike, only a minute or 2, every hour really helps, too.