Originally Posted by
drlogik
When I start to snug up the sprocket side of the wheel the wheel starts to pull to the drive-train side more than it used to.
"Pull" meaning the wheel alignment wants to shift? This sounds like your dropouts are not aligned.
The chain becoming tighter and looser at certain points during rotation is pretty common. Most chain rings and sprockets are not perfectly round. If both are pretty "out" and they hit their worst spots at the same time, you'll experience the changes in slack that you have.
Sheldon Brown has pages on how to address both issues.