E shifting? Of course not. Campy mechanical. But does Di2 or eTap have the reliability issues reported by a subset of FS owners on the web? No. But if buying a brand new already built bike which I almost never do...I build my bikes frameset up....I would have no problem with Di2 or eTap...they keep getting better and better.
I used to ride off road a bit. My go to bike was a fully rigid 29er. That is still my go to bike for off road. Compliancy through tires and pressure.