??? Are you talking about climbing hills, or what (the grammar of that sentence leaves me with no clear idea of what you're talking about)

No matter whether the weight is on the bike or on you, you still have to drag it up the hill, that's simple physics. 10 pounds is 10 pounds, whether it's in a pannier, in a backpack, or in fat around your belly, you still have to drag that weight up a hill. If it's in a backpack, you also have to carry the weight yourself. If you stand to pedal, you're lifting it a few more inches with every pedal stroke, which will add up to lifting that weight many more feet over the course of a ride than if it were on in a pannier and held at a constant distance over the ground.