I've been running/commuting with messenger bags and backpacks since the early 2000's and am very partial to Chrome. I have used a Metropolis Messenger Bag that is now used for other stuff(s). I have also had a Roll Top Ivan and have been using their largest backpack (Original Warsaw) for over 10 years. I love these things. They are very durable, completely waterproof and very comfortable.* These last 2 ^^^^ are larger one's albeit they make Medium and small(er) backpacks as well.
*commute year round in Chicago's wonderful weather