Originally Posted by veganbikes

Any good touring frame would work. Surly Disc Trucker would be an excellent choice for something frame up. We have a couple who have been coming into the shop working on their Truckers and they are awesome bikes. One of them uses Jones Loop bars and the other uses another bar and I cannot remember. You could also look at a CrossCheck or Straggler if you wanted something less totally touring bike.

I wouldn't really want to use bar end shifters on bullhorn bar personally and would rather have a good set of levers there and maybe have shifters mounted to Paul Thumbies closer to the stem. However if I was looking for more comfort orientation I would probably skip bullhorns and go with a trekking/butterfly bar or maybe a Jones loop. However if you went with Di2 then you could do a bullhorn bar with integrated shifters and brake levers which would be pretty neat and give you excellent shifting.