I get more grief from punk kids in two-doors. Pick-ups used to worry me but I have crossed path with a fair number of "good ol' boy" types without any grief at all.
Funniest one (in a away was a silver sedan came by and a high-pitched voice screeched at me out the back window. Turned out it was a little kid excited to see a cyclist. He screamed "Hi!" as they passed.
Could have wrecked me were I more easily startled, but I managed a big smile and wave. Watch else could I do?