I don't know much about anatomy, but I understand Kontact's point from experience. I've always ridden bikes with the handlebars significantly lower than the saddles, which causes me to lean forward quite a bit. On those bikes, I am perfectly comfortable on saddles about 143mm wide, like the Specialized Toupe. Last year, I bought my first bike with the handlebar almost level with the saddle, which puts me in a more upright position; none of my old fave saddles worked. I had to get a saddle that is significantly wider - about 160mm.