In the past Woman bike company founder-designer Georgina Terry mixed wheel sizes to get the top tube length shorter without excessive toe-wheel overlap..




a set of 650B wheels* with disc brakes is certainly possible given your bike has disc brakes..

Sutherlands ; '40-584 will have a radius of 335mm with that 40mm wide tire, to compare with your wheel radius.. [D 622] r=(311 + tire width/height).
say a 40 tire thats a r=351 minus 335, that's just 16mm smaller (pedal wrenches are 15mm, so that's not much)..
the BB will be lower, and the steering trail a little bit less..



* Aka 27.5"

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