Due to my age (60) and back problems (broken back and neck in car wreck several years ago) I assumed I'd need the "bull" type configuration Fizik illustrates. But I'm more comfortable on what Fizik calls a chameleon type saddle, the in-betweener.
I tried some friends' saddles with the more pronounced upsweep or up-flare in back but rather than tilting my pelvis appropriately, it just felt like the saddle was conspiring with gravity to shove me forward onto the nose. Same with the old school Selle Turbo shape saddles. Couldn't get along with 'em.
Anyway, since early February I've been riding a Selle Italia SLS Kit Carbonio, their entry level saddle in that configuration. It's pretty close to the Fizik Antares I've seen at the LBS. Minimal padding, no perineum relief cutout, 131mm wide. Suits me fine. I usually wear AeroTech Pro shorts with minimal padding (I weigh 158 lbs at the moment, trying to get down to 155).
Most folks I know locally who ride Fiziks love 'em. Different models and configurations, some with the perineum relief channel, some not, some appear to be a bit more padded. All but one person, who switched to ISM and similar saddles.
No idea about the Fiziks long term but I'd be surprised if any sort of break in applied to my Selle Italia. The construction and material appear to be designed to remain predictable, not conform. If it's not comfortable after fit adjustments and rider adaptation, it's probably not going to get any better. During the first couple of weeks I switched between my minimally padded AeroTech Pro shorts and more heavily padded Pearl Izumi with the sculpted 3D sorta padding, but soon adapted to the saddle and haven't needed much padding. But my rides are usually 20-40 miles. Longer rides might be different, we'll see.
If I make any change at all it'll be the same type of saddle with either a perineum relief cutout or channel. Other than that, I'm satisfied.
But for my hybrid I'd sure like to try a Selle Anatomica. Tried 'em on friends' hybrids. Very comfy.