Thanks for the replies. So before I went out riding this weekend I flipped the stem and it was a huge difference. I almost did not have any discomfort or pain. I believe if I shorten the stem from the equipped 100mm to 90mm my inflite would be set up perfectly for me. If I gain more flexibility down the road I could flip it back to increase the drop again.

Judging by this weekend, it's probably better going with the 56 Cannondale and not to increase the drop even more by choosing the 54 frame. I would look at other frames, but the deal I am getting with the Synapse is unbeatable... !