Ive worked with 4x5's a fair amount, and it's your decision, but I can't imagine lugging one around on a bike trip, but then folks carry laptops and whatnot also, but generally with four panniers to even the load around.
Even taking a med format, again, its up to you, but as someone who worked in commercial photography for decades, mixing a bike trip with heavy, expensive and fragile camera equipment never really appealed to me.

if you do take it, from someone who has travelled with lots of equipment over the years, including a lot of car travel , isolating your camera from vibrations and shocks is the name of the game.
Use common sense and use clothing or whatever as cushioning, and just be aware that a lot of vibrations can loosen internal screws. We've had to take Hasseblads to the repair guy to put back little screws back in and go over things after our usual shooting on location, and therefore lots of travel and transport in cars and you name it. I know a 4x5 is pretty simple, but at least be aware of what attaches to what with small screws, and perhaps take a mini tube of blue loctite if ever you start to get loosening issues, and maybe have the specific tiny screwdriver with you in case.
Same goes for the mamiya 6, although it is a fairly compact camera (lovely camera, I seriously thought of getting one once) which would be easier to isolate with foam or whatever improvised system you can do that will greatly reduce vibrations. Surrounding either with soft stuff, even a sleeping back or whatever, will help it.

and re a view camera, this isnt even touching on the space taken up by camera, let alone film holders. Even as a bar minimum, heck, if you took 5, or lets say 10 film holders, they take up space, and you would need to put each one in good ziplock bags to avoid the whole dust and crap issue, which if you shoot 4x5, you know what I mean. If not, you will just be giving yourself grieve down the road with dust issues.
I still have a Graphlex or something , "press" film holder, a doo dad that held something like 5 or 6 or 7 sheets, but in an object similar in size to a pola back, with an ingenious spring loaded "layer" system inside. Space saving, but more prone to dust. Again, havent used it in lord knows how many years now.
Its been ages since Ive touched a view camera, but all these details are still pretty relevant, especially the film holder details.
Add in a light meter too to the list of "taking care from vibrating the crap out of it" ......(but again, small , so fairly easy to isolate, but all this stuff adds up to a stupid amount of space and weight, not to mention the work involved--but its your party.
Extra film boxes, the necessary "darkroom tent" if you go that route...all extra space and weight, and I still come back to the dust issue. I was a real stickler for cleaning and loading holders, and know how a non darkroom location for loading unloading can be tricky, and has risks for both light and dust infiltration.

good luck on your project, whatever route you go, panniers and photo equip wise.