Originally Posted by
Kontact
This seems like a complicated procedure when almost every time the B screw adjustment is entirely about clearing the largest cog.
It isn't and it's not. The procedure reduces to 'shift multiple sprockets.' The reason for it, again, is that the chain doesn't reach full tension for a given sprocket until after the shift is completed. In the initiating stage, there has to be enough B-screw to prevent rub, and the amount differs with how many sprockets you want to shift at once.
Interference doesn't require an 'oddly-stepped' cassette, though there are plenty of variants that make it more probable. SRAM in particular often eschews even jumps in favor of larger ones moving into the big sprockets. I can't speak to the nuances of their (or Campagnolo's) road derailleurs.