So the bike I'm currently prepping came with 40mm Schwalbe Marathon. They feel decent, definitely plush, just wondering if there is a drawback to going big. Most of my bikes have/have had 32-35mm tires, which I enjoy, but these things look monstrous and too far in the fat direction.

Besides weight, is there any practicable drawback to a bigger tire? I've also got a new set of Conti Top Contacts in a 37 (which come out far closer to my 35 Clement USH than these 40 Marathons) I'm considering tossing on, but if there is no drawback I'll probably just run these into thr ground