Originally Posted by Mr IGH

I have done this with a 32H hub and rim. I wanted to match my 24H DT wheelset with a dyno hub and I had a smaller 1.5W hub in-hand. The bike has disc brakes so I laced the disc side 3x and the non-disc side radial. I used a DT R460 rim with 16 spokes on the disc side, 8 on the non-disc, aero/bladed. Works great, I have ~1000 miles on it without any issues. Handles just fine. I got the idea from my Mavic Askium rear wheel which is laced in a similar manner and has performed flawlessly for over 10Kmikes with my >230lbs on it.

I got a kick out of the thread ksryder referenced where the internet road-runner physicists predicted disaster on this configuration. Wasn't worth the time to try and straighten them out. An earth science background isn't not going to get them through simple statics....