Fit makes a big difference in saddle comfort. My low end Selle Italia (SLS Kit Carbonio, only $30) has about the same amount of padding as a Fizik and I was a bit worried it would feel like an a$$ hatchet, but it took only a few rides and tweaks to be perfect. But minor adjustments in saddle height, fore/aft position and angle made significant differences. Once it got those dialed in I hardly notice the saddle. But if it was off as little as 1/8" to 1/4" anywhere my sit bones complained.

And I'm wearing AeroTech Pro shorts with minimal padding on the road. Only time I wear more thickly padded shorts is when the bike is on the trainer, since I tend to sit more heavily in the saddle.

Regarding width, I'd assumed 140 or so was right for me, but my Selle Italia is 131mm and it's more comfortable. Turns out my sit bones are narrower than I'd realized. Any wider in a firm road saddle felt wrong, although I like wider saddles on my hybrids since I sit more upright.