You might notice. You might not. It only takes a couple weeks at lower altitude to pee off your RBC's. If you have enough reserve it probably won't matter too much but after 40 years of living up in the mountains the one thing I know is that there is no predicting the effects of altitude. I have gone on beach vacations and come back up here just fine and other times I can't sleep for a few days. Sometimes I lose capacity some times not.

Just stay hydrated and get some extra rest and that is the best you can do.