The Spyre/Spyke concept is nice but it's severely lacking when compared to the BB7. The main flaw they have is the lack of a floating piston, which the BB7 has. The floating piston essentially means one pad will always be in perfect contact with the rotor. If properly adjusted and setup the non moving pad will also be in almost perfect contact since the CPS washers align the caliper body.

The Spyre/spyke system does not allow for CPS washers, nor do they have the aforementioned floating piston which A) makes setup quite tricky and B) there's a high likelihood the pads will initially not contact the rotor perfectly meaning there's then bending and twisting of the pads when one brakes. This is what I suspect is the reason why spyres are extremely spongy when compared to BB7, which has a nice firm lever feel.
Also, like I've mentioned earlier, I got more power from BB7 160mm rotor than I got from Spyre 203mm rotor. Same pad compound. The BB7 road is so powerful in fact that I'm hesitant of putting a 203mm rotor on even with a full touring load. It's above and beyond more powerful than the mountain version BB7.

Also the lack of some sort of retaining system in the spyre pad adjusters just means they'll back down to their original positions. There is some weak thread locker which of course is useless after the first proper application of the brakes since threadlocker isn't heat resistant.

Spyres are also quite badly sealed (read, they're not sealed) against the elements so to keep them from seizing they do require maintenance. Problem is that TRP doesn't want you opening these bad boys so you need some exotic stuff to maintain them (T40)