Bike fit, bike fit, bike fit. You can have a great saddle, but if you are not fit to the particular bike, you will have problems. Some saddles work great when aero, some saddles are great when touring. Some saddles are great for 50 miles days, but not for centurys. Some saddles are great for 300 mile days, but suck for fast, hard races. I say Brooks for touring/long distance. Specialized Body Geometry for most general riding. Alliante for racing.