Originally Posted by
rubiksoval
I don't know about the last sentence, though. Sore glutes and hams and thighs from high exertion when you're new is pretty common. I don't think you should be sore from just going out on an easy ride, though, once you've been riding a while. Over time you'll stop getting sore at all and will just get stiff and fatigued after big days. Pain or soreness from the actual bike fit is something to be avoided. I wouldn't ride in a position that hurts.
Sorry, I didn't mean literally sore. I meant empty/tired, just as one's quads get after a long, hard ride. The emphasis was on the fact that the hamstrings and glutes should not feel untouched after a long ride while the quads feel empty. This asymmetric activation indicates inefficiency.