I have two carbon wheelsets with disc brakes for my Culprit. No issues swapping back and forth. The 55mm tall aero Token rims that came on the bike developed a rear hub bearing problem, and I got a set of Reynolds carbon 41mm for half price from the bike mfr. The mfr then put in a warranty claim and Token replaced the rear bearings and freehub on the original set, so now I have two sets. The tall 55s are tricky on windy days, so I have a set of 41s to fall back on that are much more wind friendly. Two different wheel makes with disc brakes, no issues swapping back and forth. I do have TRP mechanical disc calipers which have a spring to maintain pad clearance from the rotors, if that makes any difference from hydro systens.