I installed a Serfas Vida backwards on a front wheel a few weeks ago. This is a tire with fairly pronounced chevron pattern tread. A few miles into my ride I noticed more road noise (buzzing) coming from the front wheel than from the last time I'd run that tire (on a different bicycle). It wasn't horrible or anything, but it was noticeable. Turned the tire around and the extra noise went away. That being said, the extra buzzing was kind of cool.

-Matt