I have a CX bike with two wheelsets, and a dedicated road bike.
Wheelset 1 wears 700x35 Hutchinson Overides. Wheelset 2 wears 700x43F/38R Panaracer Gravelking SKs. The Overides are my "do everything" tire. And they're great. If it's 10 miles of pavement to get to the trails, fine. If that ride on that day only goes off the road for 10 minutes, great. They work everywhere. The Gravelkings want to be offroad. They don't care for the blacktop. But my road bike only wants to go fast, or far, or both. Sometimes I just want to do a 20 miler around the neighborhood, or some hill repeats that don't leave my guts hanging out... and maybe head home on the horse trails. Overides are perfect.
So you can definitely use two wheelsets-- as you already have a good "all purpose" set, I'd say put something more aggressive on the second set. When my SKs wear out, I'm thinking maybe Maxxis Rambler/Ravager or WTB Nanos.
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