Thanks for the feedback.
Leaning toward Osprey Talon 22- big enough, airflow & seems to be an all-time favorite. Color choices could be better.
Also tried on & liked Gregory Citro 25
My daily work commute is short, but involves hundreds to thousands of lbs of tools & materials,
so the bike trips are for various non-work activities.
Don't really get the messenger bag thing beyond an urban trips-to-the-office range, but if you say so.
IME, it's non-stop elbowing of the load out of the way.