For higher-end road bikes, there's a bigger difference than just paint colors: the geometry is different, to account for the typically-different proportions that women have (usually shorter arms and torsos). My bike, the Specialized Roubaix, has a women's counterpart called the Ruby. It's identical in every way (including price) except for paint colors and geometry of the frame (and the fact that it comes in smaller frame sizes). If a women's frame fits you better, then go for it. Honestly, I like the color choices on the Rubys better anyway; the men's bikes tend to have pretty boring color choices. But I'm over 6' with long arms, so there's no way a women's bike is going to fit me well.