Originally Posted by
Lazyass
With q/r's you usually have to make some fine tune adjustments to center the rotor between the pads when installing the wheel. Not that it's a huge deal unless you're doing a wheel swap in a race. But with thru axles they line up in the same place every time. That's the only real difference I've experienced.
I've never noticed this problem, and I've taken my (front) wheel off and replaced it hundreds of times to put my bike on the bike rack. Maybe it's different with rear wheels, though I don't remember this being an issue the last time I replaced the rear tire. Maybe I just have more clearance between the caliper and the rotor than some.