Conventionally they were always placed on the non drive side. No exceptions.

Front skewer is/was most commonly pointed backwards, but some people did set them parallel to the fork blade.

Rear skewer should be pointed up and slightly forwards, maybe 30 degrees from vertical. The reason for this is so that your rear wheel couldn't be quick released during races by somebody else's front wheel, either accidentally or intentionally.

None of this really matters. Most of it is just convention, except for the bit about the rear QR.