I almost always fit both skewer levers to the non-drive side. I always un-clip the non-drive foot when releasing my SPD shoe from the pedal. Notice I said that I usually fit the handles to the non-drive side. But...

Last year, in Jamaica, I goofed. For some reason, I fitted the front skewer with the handle to the drive side, thinking nothing of it. In fact, I did not realize that I was fitting it different from normal practice. Well...

When making a very slow speed right hand turn (difficult for me to do since breaking my neck in 2000) I started to loose my balance, falling to the drive side. I snapped my foot out of the pedal, as I was going down, intending to slap the pavement, with my forearm and cushion the landing. However, the loop of the lace on my shoe got caught in the handle of the mismounted front skewer. Down I went, jamming my elbow into my ribs, breaking one in the process. So...

From this day forward, I will always mount both skewers with levers on the non-drive side. And, from now on, the lace loops get tucked under the velcro strap.